does tirzepatide cause birth defects TLDR on GLP-1 receptor agonists (ozempic, wegovy, monjauro, zepbound etc etc) animal studies suggest a possible association with defects, low fetal weight, and miscarriage but human data (which is limited to The Project | A Massachusetts

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Mashour GA, Drissel SN, Frahm S, Farassati F, Martuza RL, Mautner VF, et al

GLP-1RAs may also have effects on a transcriptional level via protein kinase A (PKA), phosphorylating cAMP-response element-binding protein (CREB) in the nuclear membrane to enhance preproinsulin transcription [28]

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